Hotair Is Dispensible for Mouse Development
نویسندگان
چکیده
منابع مشابه
Hotair Is Dispensible for Mouse Development
Despite the crucial importance of Hox genes functions during animal development, the mechanisms that control their transcription in time and space are not yet fully understood. In this context, it was proposed that Hotair, a lncRNA transcribed from within the HoxC cluster regulates Hoxd gene expression in trans, through the targeting of Polycomb and consecutive transcriptional repression. This ...
متن کاملComment on "Hotair Is Dispensable for Mouse Development"
Amandio et al. [1] reanalyzed a Hotair knockout (KO) mouse allele previously reported by Li et al. [2]. The authors evaluated the phenotypes in different genetic backgrounds, performed transcriptome profiling of cells derived from different tissues and developmental stages, and, based on such investigations, highlighted different potential regulatory mechanisms. (e.g., cis versus trans effects)...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2016
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1006232